Peer-Reviewed Publications
Clinical Research
by Dr. Chadi Saad
Published research spanning advanced dialysis management, vascular access complications, and cardio-metabolic nephrology — contributing to the evidence base that guides modern kidney care.
While Dr. Chadi Saad focuses intensely on the operational and clinical side of advanced dialysis and nephrology care at Home Comfort Dialysis, he also contributes to medical education and clinical research. Much of his published work and collaborative research focuses on complex systemic interactions — such as how metabolic or cardiovascular crises impact internal medicine — as well as comprehensive literature reviews to improve clinical outcomes.
Featured Research & Clinical Publications
Cardio-Metabolic Nephrology
Systemic Metabolic Crises & Pancreatic Manifestations
Investigating the downward clinical spiral between Diabetic Ketoacidosis (DKA) and hypertriglyceridemia-induced acute pancreatitis (HTGAP). This research analyzes the physiological feedback loop where severe lipid overloads cause self-hydrolysis of the pancreas — a loop that leads to lipotoxicity and a dangerous downward spiral from HTGAP to DKA.
View on ResearchGateVascular Access & Systemic Complications
Intracardiac Central Venous Catheter (CVC) Complications
A massive, 4-decade systematic database review investigating the duration, clinical manifestations, and percutaneous vs. surgical retrieval outcomes of embolized central venous catheter fragments. A critical safety and procedural area for long-term clinical vascular access.
View on ResearchGateCardio-Metabolic Nephrology
Substance Abuse Impact on Hyperglycemic Crises
Analyzing the severe clinical outcomes and economic burdens of recreational drug interactions — specifically cocaine misuse — on critical hyperglycemic crises like DKA and Hyperglycemic Hyperosmolar State (HHS).
View on PubMed CentralCardiovascular Autonomic Neuropathy
Cardiovascular Autonomic Reflex Studies (CARTs)
Clinical case analyses evaluating Advanced Cardiovascular Autonomic Neuropathy (CAN) and Diabetic Autonomic Neuropathy (DAN), examining therapeutic management strategies for severe orthostatic hypotension and severe hypoglycemic unawareness.
View on ResearchGateAdvanced Dialysis & Acute Kidney Injury (AKI) Management
Paradoxical Hyperkalemia in Bartter Syndrome Requiring Hemodialysis
A critical case study detailing the management of severe, rebound hyperkalemia and acute kidney injury utilizing urgent, multi-cycle hemodialysis.
Rhabdomyolysis-Induced Acute Kidney Injury in Diabetic Emergencies
Clinical research focusing on the critical necessity of prompt creatine kinase monitoring during Hyperosmolar Hyperglycemic States (HHS) to prevent permanent nephrotoxic damage and oliguric renal failure.
Vascular Access & Systemic Complications
A Systematic Review of Intracardiac Embolization of Central Venous Catheter (CVC) Fragments
A massive, four-decade systematic database review analyzing the clinical manifestations, duration, and success rates of percutaneous vs. surgical retrieval of embolized catheter fragments. A critical safety and procedural area for long-term clinical vascular access.
Coronary to Pulmonary Artery Fistula (CPAF) Analysis
A large-scale systematic review of over 460 adult cases evaluating the diagnosis, non-invasive imaging modalities (including CT coronary angiography), stress testing for coronary steal phenomena, and surgical vs. percutaneous embolization outcomes for associated aneurysms.
Cardio-Metabolic Nephrology Research
Insulin Resistance Cascades in HTGAP and DKA
A pathophysiological literature review tracking the dangerous two-way feedback loop where severe hypertriglyceridemia triggers pancreatic self-hydrolysis, cascading into Diabetic Ketoacidosis (DKA).
Pleiotropic Effects of Substance Abuse on Severe Dehydration and AKI
A retrospective analysis investigating multi-system clinical damage, severe dehydration, and sharp increases in mortality when recreational drug interactions trigger acute kidney injury.
Published Sources
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